Early Sign In: Wednesday, October 3

2:00 pm – 6:00 pm Room 214 at The Conference Center, Harvard Medical School

Program Day 1: Thursday, October 4

6:30 am Sign In/Registration, Light Breakfast Buffet
8:00 am – 8:30 am Welcome and Overview
8:30 am – 12:00 pm Mechanotransduction
Chair: Helene Langevin MD Click session title again to hide details
Fascia is a tissue whose composition and material properties are constantly evolving in response to its changing mechanical environment. Mechanotransduction, or the ability of cells within fascia to perceive and respond to mechanical forces, is a key mechanism responsible for this fascia “remodeling”. In this session, we will discuss challenges associated with the application of recent advances derived from cell culture systems to the understanding of mechanotransduction in whole tissues, and eventually living organisms.
8:30 – 9:00 Donald Ingber MD, PhD “Tensegrity and Mechanoregulation”
9:00 – 9:30 Paul Standley PhD “Biomechanical Strain Regulation of Human Fibroblast Cytokine Expression: An In Vitro Model for Myofascial Release?”
9:30 – 10:00 Helene Langevin MD “Dynamic Connective Tissue Fibroblast Cytoskeletal Response to Tissue Stretch and Acupuncture”
10:00 – 10:30 Break
10:30 – 11:00 Alan Grodzinsky ScD “Chondrocyte Mechanobiology: Relevance to Matrix Molecular Mechanics and Tissue Remodeling”
11:00 – 11:30 Frederick Grinnell PhD “Fibroblast Mechanics in Three Dimensional Collagen Matrices”
11:30 – 12:00 Panel: Mechanotransduction (Summary Discussion, Q & A)
12:00 pm – 1:00 pm Lunch (Posters Available for Viewing in Rotunda)
1:00 pm – 3:00 pm Myofibroblasts
Chair: Robert Schleip PhD Click session title again to hide details
Myofibroblasts in fascia are connective tissue cells with smooth muscle-like contractile capacities. Originally discovered in the 1970’s, these cells are now known to play a major role in wound healing, tissue fibrosis, and pathological fascial contractures. Their evolution–usually seen as from regular fibroblasts to proto-myofibroblasts, to fully differentiated myofibroblasts, to final apoptosis–is influenced by mechanical tension, cytokines, and specific proteins from the extracellular matrix. Given its relatively recent discovery, many questions still exist about this new cell type. This session will review what is currently known about the biology of this cell, the interactions with its environment, and its presence and role in collagenous connective tissues.
1:00 pm – 1:30 pm Giulio Gabbiani MD, PhD “Evolution of the Myofibroblast Concept”
1:30 pm – 2:00 pm James Tomasek PhD “Mechanoregulation of Myofibroblast Formation and Function”
2:00 pm – 2:30 pm Boris Hinz MER, PhD “The Contractile Function of Myofibroblasts”
2:30 pm – 3:00 pm Panel: Myofibroblasts (Summary Discussion, Q & A)
3:00 pm – 3:30 pm Break
3:30 pm – 5:00 pm Concurrent Parallel Sessions I Abstracts Accepted for Oral Presentation
5:00 pm – 6:30 pm Posters with Authors in Rotunda & Refreshments
6:30 pm – 8:00 pm Concurrent Parallel Sessions II Topics by Special Invitation

Program Day 2: Friday, October 5

7:00 am Sign In/Registration, Light Breakfast Buffet
8:00 am – 8:30 am Funding Program NCCAM (National Center for Complementary and Alternative Medicine) – Partap Khalsa DC, PhD
8:30 am – 12:00 pm Fascia Anatomy & Biomechanics
Chair: Moshe Solomonow PhD Click session title again to hide details
The various viscoelastic tissue that constitute fascia(ligaments, tendons, capsules, discs, etc..) are also sensory organs. Various types of receptors capable of monitoring tension, elongation, pressure, velocity, pain , etc are located in such tissues and create a neurological feedback mechanism by which reflexive interaction with muscles is provided to maintain joint stability and safety as well as coordination of movement. Disruption of the fascia due to injury or overuse also results in corrupted feedback signals and neurological disorders that are exposing the tissue to additional potential for injury or movement disorders.
8:30 – 9:00 Frank Willard PhD “Facial Continuity: Four Fascial Layers of the Body”
9:00 – 9:30 Peter Huijing PhD “Fascia as a Collagen Reinforced Extracellular Matrix: Their Role in Force Transmission, Muscular Loading, and Some Consequences for Motor Control and Adaptation in Health and Disease “
9:30 – 10:00 Andry Vleeming PhD “Anatomical and Biomechanical Considerations of Fascia”
10:00 – 10:30 Break
10:30 – 11:00 Moshe Solomonow PhD “Ligaments as a Source of Musculoskeletal Disorders”
11:00 – 11:30 Serge Gracovetsky PhD “Is the Lumbodorsal Fascia Necessary?”
11:30 – 12:00 Panel: Fascia Anatomy & Biomechanics (Summary Discussion, Q & A)
12:00 pm – 1:30 pm Lunch (Optional Activities: a) Meet the Presenters b) Open Space Meetings/Presentations c) Posters)
1:30 pm – 4:00 pm Fascia Pain Mechanisms
Chair: Geoffrey Bove DC, PhD Click session title again to hide details
Pain is a complex phenomenon, including subjective and objective components. The objective component includes nociceptors, the neural components in the peripheral nervous system that can generate signals that can be interpreted by the central nervous system as pain. Most structures are innervated by nociceptors, which are responsive to changes in their environment that are damaging or potentially damaging. In this session, data related to the mechanisms of nociception arising from nerve fascia, muscle, and ligament will be presented.
1:30 pm – 2:00 pm Siegfried Mense MD, PhD “Neuroanatomy and Neurophysiology of Low Back Pain”
2:00 pm – 2:30 pm Geoffrey Bove DC, PhD “Epi-Perineurial Anatomy, Innervation and Nociceptive Mechanisms”
2:30 pm – 3:00 pm Jay Shah MD “Uncovering the Biochemical Milieu Of Myofascial Trigger Points Using In-vivo Microdialysis`”
3:00 pm – 3:30 pm Partap Khalsa DC, PhD “Joint Capsule Proprioceptive and Nociceptive Mechanisms”
3:30 pm – 4:00 pm Panel: Fascia Pain Mechanisms (Summary Discussion, Q & A)
4:00 pm – 4:30 pm Break
4:30 pm – 6:00 pm Panel: Clinician Scientist Dialogue
Chairs: Leon Chaitow ND, DO and Partap Khalsa DC, PhD Click session title again to hide details
The purpose of the Clinician-Scientist Panel is to offer an opportunity for interaction, dialogue, and the sharing of information between two groups, Clinicians and Scientists. Panelists represent a variety of backgrounds: including education, acupuncture, osteopathy, medicine, chiropractic, naturopathy, physical medicine, massage therapy Rolfing / Structural Integration, and pure science.
The clinicians will pose key questions relative to their work, in the hope that explanations may be offered by the scientists, as to mechanisms and processes.
Additionally the panel will offer opportunities for scientists to become aware of possible areas for further research.
Questions formulated by delegates during the Congress will also be posed to the panel.

Joseph Audette MA, MD
Leon Chaitow ND, DO (Co-chair)
Thomas Myers IASI
Michael M. Patterson, Ph.D., DO(Hon)

Peter Huijing PhD
Partap S. Khalsa, DC, PhD, DABCO (Co-chair)
Helene Langevin MD
Jay Shah MD
Moshe Solomonow, PhD, MD(hon)

6:00 pm – 6:30 pm Awards & Conclusion
7:30 pm Start of IASI Conference at the Hyatt Cambridge